The tiny tweak behind COVID-19 vaccines Prepandemic coronavirus research by Jason McLellan and Barney Graham led to a trick for stabilizing the prefusion form of spike proteins by Ryan Cross SEPTEMBER 29, 2020 | APPEARED IN VOLUME 98, ISSUE 38 The tiny tweak behind COVID-19 vaccines cen.acs.org/pharmaceuticals/vaccines/tiny-tweak... Jason McLellan holding a 3-D printed structure of the SARS-CoV-2 spike protein ... That molecule, called DS-Cav1 and published in Science in 2013 (DOI: 10.1126/science.1243283), induced 10 times ... https://cen.acs.org/pharmaceuticals/vaccines/tiny-tweak-behind-COVID-19/98/i38
Structure-based design of prefusion-stabilized SARS-CoV-2 spikes 1Department of Molecular Biosciences, University of Texas, Austin, TX 78712, USA. 2Department of Chemical Engineering, University of Texas, Austin, TX 78712, USA. 3Department of Oncology, Dell Medical School, University of Texas, Austin, TX 78712, USA. 4Center for Systems and Synthetic Biology, University of Texas, Austin, TX 78712, USA. ?*Corresponding author. Email: maynard@che.utexas.edu (J.A.M.); ilya@finkelsteinlab.org (I.J.F.); jmclellan@austin.utexas.edu (J.S.M.) Hide authors and affiliations Science 18 Sep 2020: Vol. 369, Issue 6510, pp. 1501-1505 DOI: 10.1126/science.abd0826 https://science.sciencemag.org/content/369/6510/1501.full
Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies Referred to by Daniel Wrapp, Dorien De Vlieger, Kizzmekia S. Corbett, Gretel M. Torres, Nianshuang Wang, Wander Van Breedam, Kenny Roose, Loes van Schie, Markus Hoffmann, Stefan Pöhlmann, Barney S. Graham, Nico Callewaert, Bert Schepens, Xavier Saelens, Jason S. McLellan
1 Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA 2 VIB-UGent Center for Medical Biotechnology, VIB, 9052 Ghent, Belgium 3 Department of Biochemistry and Microbiology, Ghent University, 9052 Ghent, Belgium 4 Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium 5 Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA 6 Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA 7 Infection Biology Unit, German Primate Center – Leibniz Institute for Primate Research, 37077 Göttingen, Germany 8 Faculty of Biology and Psychology, University Göttingen, 37077 Göttingen, Germany Received 25 March 2020, Revised 14 April 2020, Accepted 17 April 2020, Available online 5 May 2020.
Published: May 5, 2020; corrected online: May 28, 2020
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