Replies to post #334025 on Innovation Pharmaceuticals Inc (IPIX)

[Phoenix300]

B-ABSSI.

[williamssc]

Well it's been through the veins of some 500 participants combined in two ABSSSI trials. One trial ran by CTIX/IPIX was ran in the states under FDA.

[Blue Fin]

Cassius Longinus, 8 human trials, quote from The link:
Brilacidin and COVID-19

Brilacidin is one of the few drugs targeting COVID-19 that has been tested in human trials (a total of 8) for other clinical indications, providing established safety and efficacy data on over 460 subjects, thereby potentially enabling it to rapidly help address the novel coronavirus crisis. Laboratory testing at independent laboratories supports Brilacidin’s antiviral ability to safely and potently inhibit SARS-CoV-2. In a human lung cell line, Brilacidin achieved a Selectivity Index of 426. A molecular screening study of 11,552 compounds also supports Brilacidin as a promising novel coronavirus treatment. Additional pre-clinical and clinical data support Brilacidin’s inhibition of IL-6, IL-1ß, TNF-a and other pro-inflammatory cytokines and chemokines, which have been identified as central drivers in the worsening prognoses of hospitalized COVID-19 patients. Brilacidin’s robust antimicrobial properties might also help to fight secondary bacterial infections, which can co-present in up to 20 percent of COVID-19 patients. Collectively, these data support Brilacidin as a unique 3 in 1 combination—antiviral, immuno/anti-inflammatory, and antimicrobial—COVID-19 therapeutic candidate.

http://www.ipharminc.com/press-release/2020/10/30/innovation-pharmaceuticals-and-george-mason-university-announce-public-release-of-laboratory-testing-results-demonstrating-brilacidins-covid-19-treatment-potential

[thefamilyman]

There have been two Phase 2 human trials for ABSSSI, a Phase 2 human trial for Oral Mucocitis, and a Phase 2 human trial for Ulcerative Proctitis.

Cassius Longinus said,

I’m in a slight disagreement with a scientist on Twitter. Can anyone tell me how many FDA trials for Brilacidin have used human subjects? He claims only OM is the only trial.

[MinnieM]

Brilacidin has passed safety benchmarks in multiple clinical trials and, is currently being tested as a covid therapeutic in two US RBL’s.

Brilacidin for ABSSSI is ph3 ready. Ph2 was dosed via IV in hundreds of patients.

Brilacidin for OM is ph3 ready. Ph2 was dosed via swish and spit.

Brilacidin for UP ph 2 POC trial was dosed with water enema. Results good enough that Alfasigma licensed Brilacidin for UP dosing with foam, enema, or gel.

Brilacidin for UC ph 1 was dosed with Oralogic tablet.






Message in reply to:

I’m in a slight disagreement with a scientist on Twitter. Can anyone tell me how many FDA trials for Brilacidin have used human subjects? He claims only OM is the only trial.