Replies to post #125469 on Cytodyn Inc (CYDY)

[Rockleo]

ombowstring...Restoration of Immune homeostasis..CD4.. CD8 Cells.. being realigned with their Natural function..CD8 Cells reverting to killing Viruses rather than harming our own body tissues..As occurs in the Cytokine Storm.. The immune System going haywire..and Leronlimab’s ability to revert this change is the basis of its MOA....

Ohms hypotheses..Brings ANOTHER MOA ..Which May explain Dr BP’s finding of lowered viral load..!!!

IMHO..

[misiu143]

Sorry ombowstring , not home until much later ..

[CTMedic]

Ombowstring,

Virus enters and infects cells through Ace2 and apparently neuropilin. Viral hijacks cellular apparatus to reproduce.

Infected cells release cytokines and chemokines inducing the immune response to fight infection.

The initial response is the innate immune system (macrophages, natural killer cells, neutrophils) to kill infected cells and ingest virus. The innate system response is quick but not terribly specific.

Excess innate response floods lungs with inflammatory cells, creating a vicious cycle of more chemokines (chemotaxic cytokines summoning more macrophages).

Leronlimab blocks CCR5 on macrophages interrupting this vicious cycle.

It also blocks CCR5 on lymphocytes, reversing exhaustion, allowing them to interact with antigen presenting cells to learn to recognize the virus. The more specific response of the adaptive immune system eventually eradicates the infection.

Regeneron mAb and remdesivir fight the viral stage, but are not helpful once immune system is dysregulated and cytokine storm, profound inflammation has ravaged the body.

Leronlimab (rlf-100, Lenzilumab) reduce the cytokine storm and the inflammatory damage as well as restores the immune system so that it is able to resume its own antiviral response

[misiu143]

Ombowstring - Sorry I was out , I VOTED !!!!!

I am reading some posts , and there are a very good explanations ..

I will just add a little, I know how by blocking CCR5 we quieting cytokine storm , repair immune system , and then indirectly with healthy immune system reducing viral load ..

But I actually didn't know if we may also work directly on the virus since we don't block ACE2 receptor coronavirus using to enter into the cells where it may multiply...

Ohm , said something in the past that maybe it is possible , but today article he posted gave me more information..

So there is this second receptor- neurophilin-1 .

And the second receptor coronavirus uses to make it easyer to invade cells , helping virus to get to ACE2 , and we downregulate this second receptor ,
this may explain why we are showing positive effect with patients even in the early stage of COVID 19 ,

The same receptor they notice also in HIV , Ebola and highly pathogenic Influenza.

Very exciting research , and my thanks to Ohm..