"provided are methods of treating a subject having a CD56-positive cancer, and methods of inhibiting tumor growth or metastasis of a CD56-positive cancer in a subject. In some embodiments, the methods include selecting a subject with a CD56-positive cancer and administering to the subject a therapeutically effective amount of an ADC or composition disclosed herein." -------------------------------------------------------- "Boca Raton, FL, Oct. 16, 2020 (GLOBE NEWSWIRE) -- Connectyx Technologies Holdings Group, Inc. (OTC: CTYX) (“Connectyx” or the “Company”), a development-stage biomedical company focusing on novel treatments for rare diseases today announced it has entered into an Exclusive Evaluation and Commercialization Option License Agreement with the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), for use of a novel monoclonal antibody in an antibody-drug conjugate to treat brain cancer.
The licensed patent rights include US Patent No. 10,548,987 issued February 02, 2020 (Patent Application No. 15/747,620 filed January 25, 2018). HHS Ref. No. E-221-2015-0-US-03. “ANTIBODY - DRUG CONJUGATES FOR TARGETING CD56 - POSITIVE TUMORS.” The territory is worldwide.
While the field of use covers treating adult and pediatric Glioblastomas, the Company is targeting pediatric Glioblastoma, an orphan disease, as the first indication for this product.
Paul Michaels, Chairman and President of CTYX said, “We are pleased to have added this cutting-edge technology to our development portfolio. Pediatric Glioblastoma is one of the deadliest childhood diseases with an average survival rate of less than two years.”
Michaels concluded, “Recognizing the urgency for these patients and their families to find treatment options, our development plan anticipates being prepared for our First-in-Human clinical trial within 18 months, and our goal is to create a combined phase 1/phase 3 trial to accelerate development. We know these are extremely aggressive goals, but this is an extremely aggressive disease.
At CTYX, we are building a pipeline of potential breakthrough medicines all of which can have an accelerated development pathway.”
About Pediatric Glioblastoma
Roughly 28,000 children are living with a primary brain tumor in the U.S. with approximately 3,700 new diagnoses each year. Brain and CNS cancers are the most prevalent of all childhood cancers. The five-year survival rate depends on the size, location, and makeup of the cancer; for the most aggressive Glioblastoma, it is less than two years.
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