It is true that the person providing treatment dose know and may unintentionally treat the patients differently. Highly unlikely but there is a reason we run blinded trials
Not all are unconscious.... Cannula's are used on patients still conscious. And not all Respirator patients are "unconscious" They are given drugs to out them in a induced coma but they can frequently wake like Dr. Adeline Fagan was doing on her respirator for over 40 days until she finally succumbed