animal testing is NOT a “more advanced efficacy test” than using human cell lines.
Of course it is. In animal testing the drug has to prove that its delivery mechanism works in a system that somewhat resembles a human system...vessels, membranes, pumps, etc.
Cell tests are are just directly applying the drug to cell cultures. None of the complexities of delivery apply in that case.
I think Brilacidin is going to work quite well against COVID in humans but it doesn't change this argument one bit.
In vivo testing is almost always a superior standard of efficacy test than in vitro. Does it always work? No, of course not - Prurisol is a shining example of that.
When we get some efficacy data in in vivo or clincical studies for B-COVID I will happily say we are "beyond hamsters and mice".
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