Two common immortalized cell lines go by the monikers HEK-293 and HeLa. HEK-293 is a cell line isolated from a human embryo that was electively aborted in the Netherlands in 1973. Catholic leaders and other antiabortion groups have objected to the use of HEK-293 in the development of some COVID-19 vaccine candidates. Cells derived from elective abortions, including HEK-293, have been used to develop vaccines, including rubella, hepatitis A, chickenpox and more. Other fetal cell lines, such as the proprietary cell line PER.C6, are also used in vaccine development, including for COVID-19.
Stabilized prefusion spike vaccine candidate induces powerful immune response to achieve this, the current study uses vaccines based on transgenes delivered by recombinant adenovirus type 26 vectors (Ad26) incapable of replication. These are known to be safe in humans but to elicit neutralizing and binding antibodies, as well as cellular responses based on CD4 and CD8 T cells, culminating in a Th1-based response. The fact that these transgenes are suitable for scalable and industrial processes makes it a very viable option for vaccine development.
The study sums up, “Ad26.S.PP, from now on named Ad26.COV2.S, was identified as our lead SARS-CoV-2 vaccine candidate and is currently being evaluated in a phase I clinical trial.”
News 
Market Data 
Discover 
