Replies to post #115285 on Cytodyn Inc (CYDY)

[JLA Ins]

Ahhh. Chosen narratives yet again Grip. The pledge was due to safety and we have proven not only safety in over 1000 patients but also have years of no adverse effects. YEARS! Not months like vaccines. Today’s lesson for you bud.

[Borel Fields]

Grip - it's a body of work: 84 m/m + 195 s/c + 61 EIND = 340 COVID pats already, plus

(1) Safety - we have >1k pats w/ safety data - others have proven worse record or are newbies lacking data, and

(2) Efficacy: square root rule - if you have half the effect, you need four times the trial size to detect it.

All longs here believe in a minimum 50% reduction in mortality in S/C and 50% reduction in progression of m/m to s/c (data: m/m NEWS2 80% LL improved vs. 50% control)

So, considering the RCTs together, compared to a drug targeting half that, in terms of stat power for proving efficacy, we already have data matching a 1,000 person trial.

Of course, each trial was/will be on its own statistically significant on its relevant endpoint. The body of work will be "big enough" and have unmatched consistency.