Replies to post #320646 on Innovation Pharmaceuticals Inc (IPIX)

[roiresearch]

We are on the outside looking in. Since we have this MTA in place we are not sure what IPIX can and can't report at this time. Per the June 5 GMU announcement ipix paid for the ec50 value. Leo said this was so we could proceed with the ind. Maybe the data we received to date was on the path to obtaining this value. Who knows what other testing may have happened since March? It obviously guided ipix in coming up with the July 13 pr as you pointed out. Cant believe this would be a shrug of the shoulders kind of decision

[loanranger]

"Preinfected cells? Or postinfected? it was not clear to me. Because preinfection was reported to have much much higher kill rate(97%, was it) it must be postinfection. How good is 50% inhibition in a lab for infected cells?"

Here's the language they used:
"In a new experiment at the RBL in a human lung epithelial cell line, Brilacidin, when directly incubated with the live (or wild type) virus, was shown to inhibit the virus by 50 percent (the IC50 value) at a mid-nanomolar concentration, while remaining non-cytotoxic to cells at high micromolar concentrations—establishing a SI for Brilacidin greater than 300 in this lung cell line."


I can't figure out the pre vs post infected stuff...(somebody must know what "directly incubated with" means)...but the GOAL was to determine the concentration at which the virus was inhibited by 50%, not to determine how much B inhibited the virus as your question seems to suggest. I THINK that needed to be done at least in part in order to calculate the magic Selectivity Index.


The answer to this question appears to be irrelevant (not suggesting it's not meaningful)...
"How good is 50% inhibition in a lab for infected cells?"

...as does this conclusion:
"Because preinfection was reported to have much much higher kill rate(97%, was it) it must be postinfection."



Am I wrong?