Replies to post #320568 on Innovation Pharmaceuticals Inc (IPIX)

[Jhawker]

Looks like B is looking good!

[Minnesinger]

Thanks for posting this...

Different labs will get different SI with different methods (and random variability).

I had been wondering the very same and haven't been able to find anything definitive online. (Admittedly, I haven't spent a lot of time looking. Just that nothing immediately presented itself.) I'm happy to believe you're qualified to know and I'll take it as truth. Cheers

[loanranger]

"Different labs will get different SI with different methods (and random variability)."

The Selectivity Index is a measure that I hadn't heard of until recently and the accountant in me gets nervous upon hearing a sentence like that. The much anticipated SI number created a fair mount of excitement....at least around here and it's disconcerting too find that it's not a function of a clearly defined formula (at least to me it's not).

"Good to see high SI, and that will begin the process of FDA interaction in a few weeks."
So, in spite of all the variables that could play into the resulting number, the FDA relies heavily on it in deciding whether or not an interaction is called for?

I know it's an oversimplification but it seems to be a ratio of sorts that grows larger based on the safety of higher concentrations and the effectiveness of lower ones. Can an extremely safe compound result in an extremely high SI in spite of being relatively ineffective?
Asking for a friend :o)

If it's more palatable we can pretend that the question comes from the 2200 SI of the nasal spray. I guess it gets to the virus without entering the bloodstream, which could account for its level of safety.