Replies to post #317681 on Innovation Pharmaceuticals Inc (IPIX)

[PlentyParanoid]

In sane world Vero cell quandary should benefit Brilacidin.

Downfall of hydroxy
As I said before (tooting... post #317698) it looks like the only thing hydroxy might do is preventing corona virus from entering blood, provided that one takes it in time, preferably from birth. This, however, does not prevent one from dying of Covid-19. The final exit just comes different way, suffocation due failing lungs instead of heart attack, or kidneys quitting. Ah, choices...

Pretender in Trouble?
ViralClear's merimepodib, the one that scored 98 % viral inhibition, may have the same problem as hydroxy. As far as I can find stuff[1], in vitro was done with Vero cells. Furthermore, it looks to me that the process inhibited by merimepodib [2] results in proton release [3]. [SWIKAI STARTS] My questionable memories from high school chemistry classes are telling me that adding proton should change pH level, a la hydroxy. It all depends how important IMP to XMP process itself is for viral proliferation - pH level maybe meaningless in case of merimepodib.[SWIKAI ENDS]

Be it as may, this late enlightenment about Vero cells should strengthen the case for Brilacidin.

[1] https://f1000research.com/articles/9-361

[2] Inosine 5'-monophosphate dehydrogenase (IMPDH) catalyzes the nicotinamide-adenine dinucleotide (NAD+)-dependent oxidation of inosine 5'-monophosphate (IMP, 1) to xanthosine 5'-monophosphate (XMP, 3), the first committed and rate limiting step in the biosynthesis of guanosine monophosphate
source:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810100/

[3] https://en.wikipedia.org/wiki/Inosine-5%E2%80%B2-monophosphate_dehydrogenase

SWIKAI: Speculation With Insufficient Knowledge And Intelligence

[KMBJN]

Glad others are raising awareness of this issue of Vero cells and SARS2 entry that we discussed a few weeks ago here:

https://investorshub.advfn.com/boards/read_msg.aspx?message_id=157089448