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Minnesinger

08/04/20 9:59 PM

#317144 RE: williamssc #317105

I agree that an inhaled delivery method...

would be the most expedient path to commercial production as a prophylactic. However, like any prophylactic, it only works if you use it. I wonder what sort of patient compliance metrics we might see in nebulized form?

It's one thing to take your medicine if you're grappling with the symptoms of your illness and carrying the burden of your affliction. You'll do what it takes to get better. It's another thing altogether if you perceive yourself as healthy. I'm sure the medical professionals among us could elaborate on the challenge of patient compliance in their treatment plan. This is why I was questioning the viability of a time-release patch or implant: set it and forget it.

Clearly, this is more of an intellectual exercise than anything else. To reiterate, I believe the most expedient path to approval as a prophylactic would be an inhaler. Though, I don't believe it would be foolproof.

loanranger

08/19/20 8:42 PM

#319428 RE: williamssc #317105

"I like the idea of a nasal spray as viruses can start out in the nasal pathways."

https://www.ucsf.edu/news/2020/08/418241/aeronabs-promise-powerful-inhalable-protection-against-covid-19
https://www.biorxiv.org/content/10.1101/2020.08.08.238469v1

"In an aerosol formulation they tested, dubbed “AeroNabs” by the researchers, these molecules could be self-administered with a nasal spray or inhaler. Used once a day, AeroNabs could provide powerful, reliable protection against SARS-CoV-2 until a vaccine becomes available."

Once a day???!!!!