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Really People

08/02/20 4:18 PM

#62206 RE: DM797 #62204

It’s either the same or similar

Not my strong suit but here is what I found

Sunshine Bio Site quoted

“One of these functional proteins is a cysteine protease referred to as the main protease (Mpro, also called 3CLpro and nsp5). “
Quote from a different articles which mention out compound quit a bit.

“Therefore, the continued development of therapeutic and prophylactic countermeasures to potentially deadly coronaviruses is warranted. The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses.”
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896749/.

3CLpro is another name for Mpro the main protease