Number of shares is all relevant to the investors personal situation.
Also, IPIX being so high risk (at least up to about 3-4 months ago) I consider anybody invested in it was pretty much all in (unless they only held 5-10K shares).
I know of some with 30K shares and it is a monster investment for them.
I know of many in the six figure range (from 100K to 950K) and they all consider their positions as large, many extremely large.
I also know quite a number in the 7 figure range and some of these are in much deeper than their financial condition would consider prudent, but they to a person believe 100% in the science of B and K and the success of the company.
I don't look at the number of shares, I would consider instead where IPIX ranks in your portfolio of stocks as to whether it is a major investment or not.
Bottom line: I have much more respect for those that have little and have wagered much on the success of IPIX as compared to a rich person that has a lot of shares but whose overall financial situation will not be changed even if it fails.