Why more people in leron than lenzi phase III: 1) leron trial is 2:1 randomization - not as statistically efficient, (2) More patients ==> greater statistical resolution. If you want to make sure the trial detects a (underlying, long term) 50% reduction in deaths, you need fewer people than to be sure of detecting a 30% reduction. (3) Humanigen's endpoint is easier, so they are betting on big.