Borel.. As soon as the patient signs the Informed Consent you register them thru IVRS.. Similarly when you then Randomize that patient.. You register them thru IVRS.. and the patient is placed in the treatment or placebo arm of the trial..
The Company knows Instantaneously how many patients are in Screening.. Screen failed.. Randomized.. They send all sites this information every 2-4 weeks.. so as to know when to stop enrolling patients..