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loanranger

04/01/20 1:04 PM

#289567 RE: noretreat #289551

"Another point not really being discussed."

I tried several hours ago and the issue was gobbled up on a technicality. The results suggest some potential as a treatment but they MEASURE its use as a prophylactic...in healthy subjects.

Jhawker

04/01/20 1:06 PM

#289568 RE: noretreat #289551

Or how would anti-inflammatory properties and antibiotics help patients.

farrell90

04/01/20 2:09 PM

#289630 RE: noretreat #289551

That is a good point which I overlooked when I read the PR. I do not believe the purpose of the test was to do anything other than to show an antiviral effect. It should not predict a preventive or prophylaxis benefit but I would be happy to have someone with more experience to correct me.

I was expecting the test to performed on infected cells with Brilacicin introduced after the infected cells had incubated.

There are a number of different ways to test for an antiviral effect.

https://www.ibtbioservices.com/bioservices/antiviral-testing/

Have you bought back in?

GLTA, Farrell

MinnieM

04/01/20 5:05 PM

#289775 RE: noretreat #289551

There are a lot of questions that still need answering. And, I agree about the likelyhood of quick follow-up testing.





Message in reply to:

There definitely will be quick follow-up to this with next steps. I expect Leo to keep this in front of everyone for a while...

Another point not really being discussed. The graphic shows B's potential as a prophylactic. B was introduced to the cell cultures BEFORE the virus and the viral load was compared later. The higher dose of B reduced viral load by about 50% if I'm reading it correctly. I wonder what would happen if B was introduced AFTER infection....