HER2-Vaxx (developed by Imugene) induces polyclonal antibody responses against a speci?c epitope of HER2 and is being tested in patients with HER2-positive gastric, esophageal, and breast cancers. In the current vaccine, the HER2 peptide is formulated using the carrier protein CRM197, a non-toxic mutant of diphtheria toxin, combined with an adjuvant, whereas the previous formulation used virosome-based materials.