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01/31/20 7:07 PM

#142701 RE: Inspector121 #142700

NNVC's technology is to mimic the cell to the virus, such that the virus attaches to the nanoviricide and is then destroyed. Each virus (and different strains from the same family) enters the cell via a different cellular receptor, which the different nanoviricides mimic with a ligand attached to the core nanomicelle. For MERS-CoV it was DPP-IV for the cellular receptor that MERS-cide ligand mimicked. For SARS-CoV it would be ACE2, which is what Diwan was talking about in today's PR. For the new Wuhan 2019-nCoV, the viral S spike uses something unknown to enter cells, in my mind based on this new paper. The new S spike is a combination of amino acids from HIV and SARS, so could use ACE2, CCR5, CXCR4, all of the above, or something else.

Basically, in my mind it means NNVC/Diwan has no idea which cellular receptor to mimic to defeat 2019-nCoV. He says he has a library of ligands to choose from, but he has no way to even test anything he creates in a lab, since it requires a BSL-4 lab to test on live 2019-nCoV virus in cells. Not to mention, NNVC has no money for this, nor any license.

So, it doesn't really matter, since NNVC probably won't get any money to develop a 2019-nCoV-cide anyways, based on past history.

Just thought the science about the viral genome was interesting and thought I'd share.

I actually sold some of my NNVC today on the pop to $17 and bought something else.