Here is the HEAT subgroup data timeline I get from CLSN website:
May 20, 2012: HEAT enrollment completed.
Jan 31, 2013: HEAT results.
May 17, 2013: First time, subgroup data HR=0.65, P=0.105
Sept 16, 2013: subgroup data HR=0.623, P=0.058
Jan 27, 2014: subgroup data HR=0.64, P=0.0495
Dec 30, 2014: subgroup data HR=0.65, P=0.037
July 15, 2015: final subgroup data HR=0.65, P=0.02
It is very clear to me OPTIMA final HR is set which
means success or failure known to DMC, only P value
may change, if Theromodox is working as expected like
HEAT subgroup data has shown, P value may go lower to
increase the level of SS.