Replies to post #494 on Dyadic International Inc (DYAI)

[tykundegex]

G0 glycan levels of up to 95% have been reached with this strategy. In addition to G0, only Man3and GlcNAcMan3 remain in the glycan pattern.

The glycan pattern remained good with 93-95% G0 glycans.

Summary from VTT:

? Myceliophthora thermophila C1 is an industrialized protein production host that is now developed for therapeutic protein manufacture - with several large biopharma companies entering into collaborations.

? We have identified critical proteases to deal with for therapeutic protein production enhancement and enabled a very significant reduction of the protease load in the production strains.

? Our glycoengineering program aims at high proportions of human glycoforms G0, G2, FG0 and FG2. Excellent G0 levels have been reached through alg3-alg11 deletion strategy.