Replies to post #274282 on Innovation Pharmaceuticals Inc (IPIX)

[farrell90]

Nice...who said it could not be done!

Thanks for posting

GLTA, Farrell

[frrol]

This will not replace the B-UC pill. The mechanism is micro-needles of freeze-dried insulin which injects the drug for systemic availability. B-UC (and UP) needs to coat the wall, not be injected.

It could potentially replace B injections or infusions for ABX use. It would require among other things that B remain stable in the freeze drying process.

[kfcyahoo]

"Nice to know that if the B-UC tablet technology doesn't pan out there's the capsule technology waiting in the wings. Assuming both technologies work, I wonder if Leo will do a study with the capsules to see if it works better than tablets?"

Two big names(M.I.T and Novo Nordisk), hopefully someone thumbs from Beverly to Cambridge to speak with Giovanni, couldn't be much closer.

Lot of research into diabetes(including tcells clilnical trial at Joslin in Boston). As a long time t1d'r(type 1 diabetic), thanks for the post.

[loanranger]

"Nice to know that if the B-UC tablet technology doesn't pan out there's the capsule technology waiting in the wings."

I could be mistaken but.....
PH triggers like the one in the capsule have been used in pills before. In fact several colitis treatments work that way....a polymer coating erodes away based on the higher PH in the lower small intestine and the drug is released. IPIX theoretically COULD do that with Brilacidin. The BDD tablet trigger is time based so IN THEORY it could deliver Brilacidin anywhere along the digestive tract, which distinguishes it from the PH based delivery systems and I'm pretty sure that's the Whoopee! part of the plan.

Again, I could be mistaken, but I believe the capsule is being used to carry material the physical nature of which couldn't be implanted and transported in a pill.

The thing that would be waiting in the wings in terms of a delivery system to the colon for Brilacidin is the same PH triggered pill that's already in use, not the capsule.


I look forward to the onslaught of corrections that is sure to follow.