Something that struck me and made me reflect was the term ROW, Rest of the World. Knowing GTCB retains marketing rights for Atryn HD, Atryn DIC and rhFactor VIIa outside Europe (and Canada+ME for Atryn), we basically tend to think of the US and Japan. However, at the pace middle classes in Asia and Latin America are growing in number, by 2010 the market for expensive medical treatment in the Rest of the World is probably more than double or triple that of the US. Such underestimation of the ROW (if it applies) makes the projections of the growth potential of the market for GTCB plasma replacement products likely very conservative.
Connected to this reflection, whenever GTCB will be taken over (which I think is finally inevitable) these marketing rights will/should carry an important price tag.