Replies to post #1073 on Alaunos Therapeutics Inc (TCRT)

[jondoeuk]

''These guys seem to be on the cusp of a cure for cancer.''

Sadly, that is not the case as there are a number of ways cancer cells can become immune to T-cells. Some of these are loss of target antigen(s), HLA, altered interferon or TNF-a signaling, and epigenetic. Some of the latter could be addressed with 5-azacitidine [1] or HDACi [2,3].

Refs:
1 https://www.nature.com/articles/bjc2011428
2 https://www.sciencedirect.com/science/article/pii/S0952791510002074
3 https://www.futuremedicine.com/doi/abs/10.2217/epi.15.16