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Spideyboy

05/16/19 11:55 PM

#22537 RE: Auto1 #22488

Given your understanding then others might be confused about this too.

It is highly doubtful R18 will be used in the field of battle. As no-one would knowingly send troops into an area which might be bombed with a nuclear weapon even if they were injected beforehand. And if you don't mean a nuclear weapon, I don't believe any country has developed a portable weapon for use on the battle-field that directly should radiation at the enemy. Rather they would send in troops to the effected area to aid in speedy evacuation/support of a population population in the affected area. Hence the troops in question would be injected prior to going into (and maybe after coming out of) the radioactive area.

Nuclear power-station incident such as a Fukushima incident would be a far more likely as we have seen than all out thermonuclear war. This means relative planning before sending troops in will be possible and ethically a must. Also regards the thawing, this is not a major issue. Transporting hundreds of billions of cells worth of doses in a liquid nitrogen vat is a simple task. Pluristem has developed a specific small table-top point of care thawing device to enable automated fast thawing for clinically effective product. The device clearly works as that is the basis for the Dec 2018 deal with Chart.

If R18 cells were to be shipped to differing destinations, one would assume that these would also be shipped with a proportional amount of thawing devices.

In an emergency scenario, hospitals would be the primary location for these injections, but one would not need to only use an operating theatre for injection. One might also imagine the hospitals setting up small tents or mini-clinics outside the hospitals to deal with the numbers of people needing the injections. All you need is a space for the person to lay down to receive the injections. Mains or a generator to power the thawing devide and a needles to inject the product.

Based on the CLI trial, we know that 300 million cells are in 15ml of PLX-PAD. If going with what appears to be the most effective NHP R18 dose of 10 million cells per Kg, then we are averaging about 700 million cells per person. If the concentration of R18 cells in their vial is the same as for PLX-PAD then that would require about a total 35 ml injection. Such injections would be easy to inject in any non-extreme temperature environment.

Thus the storage and transportation of billions of cells is simple, thawing is rapid, and administration simple. Though I agree each hospital will need more than one thawing device, but that would not seem a difficult thing to procure as Chart bought the rights for global commercialisation and as mentioned one would think the government would be smart enough not to ship enough doses for 100,000 people with only one thawing device.

Great in hospital, and clearly battle field use is an exaggeration. The other potential situation you might have entertained is a dirty bomb. Of which no dirty bomb has ever been set off in warfare. Mostly just irradiating the fools who handled it. https://en.wikipedia.org/wiki/Dirty_bomb

Looking at the more plausible scenario of nuclear power station incident likelihood, the US is clearly top of the list with 99 operational Nuclear Plants and another 2 currently under construction. 2nd Place France with 58 and 12 more countries with a range of 7 to 42 nuclear power stations. Japan being 3rd with 42. https://en.wikipedia.org/wiki/Nuclear_power_by_country
Given the experience in Japan, all relevant countries need to have the appropriate countermeasures to the possibility of it happening again.

Thus one would imagine a government having enough cells to be strategically stationed nearby these plants, and then additional stocks in heavily populated areas. This strategic distribution is largely obvious and thus based on the relevant populations will stock the necessary cells and corresponding number of devices.

No elephant. Hope we see good DOD results.