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drragmop

11/16/06 11:06 PM

#9764 RE: xzoneclone #9763

I saw those, but when I saw "Vatuximab," I turned away thinking it wasn't us. "Vatuximab" does not appear on the PPHM website, and I do not recall it. I have found it in some documents dating to 2004.

Did "Vatuximab" have a short career as the in-house name for what, last year or early this year, was given the USAN name "Bavituximab?"
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jazzbeerman

11/17/06 8:00 AM

#9766 RE: xzoneclone #9763

zone/drag,

Wow. That's quite a few govt sponsored bavi cancer projects from 2005 that we could hear results of (if they were good and why would they not be) anytime I suppose.

I'll add those to my list of preclinical cancer related things I look forward to hearing about, which includes-




* bavi plus radiation brain data

* bavi/tTF conjugate data

* TNT/tTF conjugate data

* bavi/radio-arsenic conjugate data for imaging and therapy

* bavi + anti-PE combo therapy

* anti-PE solo therapy

* newer molecules called "betabodies" (a pair of B2GPI's connected to an antibody Fc)

* newer molecules called "receptorbodies" (a PS receptor connected to an antibody Fc)

* detailed studies/proof into the cancer-specific immune-modulating mechanism of 3G4. (It's been proven in several other labs, which I've posted here, that blocking PS does "block PS immunosuppressive signal" and heighten the immunogenicity of apoptotic tumor cells, but I'm not aware of any detailed 3G4 experiments into it.)



j