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Antti

04/26/19 6:54 AM

#10066 RE: Theburg #10065

I think that's actually the part where they got p<0.001. The actual endpoint had p<0.012. The difference is fairly easy to understand. The likelihood to get these results just by pure chance is much larger at one single point in time. But when you see a similar effect at each point in time the chance that it's just random fluctuation becomes much smaller.

The longer one looks at these results the better they become. Or as Alkon said "look at the data, look at the data, just look at the data".
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runncoach

04/26/19 6:57 AM

#10067 RE: Theburg #10065

TheBurg, A year or two ago Biostudent asked me what was my most important take away from the data as the more complete picture was coming in, and it was the point you mention. I had broken down every group both on the drug and on placebo, on memantine and not, on 40 ug and on 20 ug and all showed a positive trend with bryostatin although most not stat sig...but EVERY SINGLE PATIENT who showed improvement at 5 weeks showed improvement at every single data point thereafter in the non memantine population with 20 ug dose. Plenty of drugs show improvement at 5 weeks (placebo anyone?) but we show again at week 9, 13 and 30 day followup after showing it at 5 weeks. That was a real head turner for me. JMHO