Replies to post #96249 on Ayala Pharmaceuticals Inc (ADXS)

[mypekeispooped]

Thank you for being one of the voices of reason and sanity here. Obviously, neither Amgen nor Merck had enough clinical evidence to assess the efficacy of the treatments despite the claims of others. I'm hoping more light is shed on the responses of the six patients. There appear to be a number of patients (23) in Part B <50% PSA decline from baseline (according to the slide on the CP) who had not had an event, also. Would to hear an update on them.

[ignatiusrielly35]

Hov, why is it always said that results are not expected from a Phase 1 due to it not being designed for efficacy? Assuming that the optimal dose has been determined, why would efficacy not be determinative? It is theoretically the same construct that would be used in a pivotal trial, no? In this particular trial, I mean. Thanks.