I’ve been following this group since the $0.01’s and have been thinking of posting this for a while. This is my first post on this website actually, but of all the stocks I’ve followed I feel like $CELZ has the greatest potential to be $10.00 and above.
As my profile name suggests I am a physician (training as a 1st year resident) and I was introduced to this stock by one of our attendings who held a financial seminar earlier this year. As you can imagine, most of us graduate with crippling debt from medical school (where a good portion of our salary is shoveled to) which is why he held these seminars – to teach us some of his experience with bonds, stocks, and business, and the importance of investing our hard earned income.
So during his similar there were talks of some bio-medical stocks and Creative Medical Technology Holdings Inc (CELZ) was discussed as a potential stock to look at. There were others, but due to my field ED treatment seemed like familiar territory for me. I’ve since then looked into it and have read the various research and DD posted here and I’ve got to say I’m impressed! Today I want to contribute some knowledge from the inside perspective of the field everyone here is heavily invested in. Just note that this is WHY I BELIEVE this stock will grow, you can look at this any way you want but please do your own DD before you fully jump on board.
These are some of the things we learn in medical school up to residency and are found in most of our text books and step reviewers. My main source will be Harrison’s Principles of Internal Medicine, 19th edition since that’s what I currently use. I also took a look into the research articles on the CaverStem website themselves (most of them were just abstracts, but I managed to find the full articles and linked here to share in case you’re interested).
Overall, amazing work by the CaverStem team! __
So first of all, how prevalent is ED? In the National Health and Social Life Survey (NHSLS), which included a sample of men and women age 18–59, 10% of men reported being unable to maintain an erection (corresponding to the proportion of men in the MMAS reporting severe ED). Incidence was highest among men in the age group 50–59 (21%) and men who were poor (14%), divorced (14%), and less educated (13%). By 2025, experts predict that 322 million men will have ED worldwide. This is an increase from the estimated 152 million men with ED way back in 1995 (Aytac, McKinlay, & Krane RJ., 1999).
“The incidence of ED is also higher among men with certain medical disorders, such as diabetes mellitus, obesity, lower urinary tract symptoms secondary to benign prostatic hyperplasia (BPH), heart disease, hypertension” (Kasper, et al., 1999)
So we know that ED will continue to climb thanks to its close connection to the prevalent lifestyle diseases mentioned above (hypertension and diabetes being to most common). CMTH, Inc. (CELZ) is not only targeted here in the US, but will be spreading out internationally as well. Imagine how many patients this could potentially be used to relieve the burdens that come with ED.
So to know what is abnormal about erectile dysfunction (ED) we’ll need to know what the normal physiology is like. The normal male sexual function requires:
(1) An intact libido (2) The ability to achieve and maintain penile erection (3) Ejaculation (4) Detumescence (tumescence means engorgement due to vascular congestion).
A lot of problems can come from (1) (no will to have sex in the first place), but those can usually be treated by treating the underlying cause; such as stopping certain conflicting medications or treating abnormal hormonal irregularities for example. Our focus of concern will be (2) as CaverStem targets the inability to get an erection and maintain it (the will is there, but the equipment is malfunctioning).
To understand what’s happening we should define what exactly leads to and maintains an erection.
The corpora cavernosa (or cavernous bodies) contain most of the blood in the penis during an erection. Penile erection depends on an increased flow of blood into the lacunar network within the cavernosa accompanied by complete relaxation of the arteries and corporal smooth muscle. The problem happens here when blood is unable to completely engorge these channels. This is essentially the target of CaverStem, hence the name (Cavernosa + Stem cells).
Of all of causes of ED the most common organic cause of ED is vascular disturbance. Atherosclerotic or traumatic arterial disease can decrease flow to the lacunar spaces, resulting in decreased rigidity and an increased time to full erection. Excessive outflow through the veins despite adequate inflow also may contribute to ED. Structural alterations to the fibroelastic components of the corpora may cause a loss of compliance and inability to compress the tunical veins. This condition may result from aging, increased cross-linking of collagen fibers induced by nonenzymatic glycosylation, hypoxemia, or altered synthesis of collagen associated with hypercholesterolemia.
So how does CaverStem fit in to all this? “The possibility of using mesenchymal stem cells in the treatment of ED is enticing because these cells are known to secrete various growth factors that are beneficial in ED such as IGF-1 [133-135], VEGF [136], and FGF-2 [137], but also because of their anti-inflammatory activities [138], as well as possibility of differentiating into tissue relevant to the penile architecture [139].” (Ichim et al., 2013)
I really want to break this down for you: IFG-1: Is commonly known to help build muscle and is also crucial in healing FGF-2: This protein has been implicated in diverse biological processes, such as limb and nervous system development and wound healing.
And now here’s the really important one -
VEGF (Vascular endothelial growth factor): This stimulates the growth of blood vessels.
CaverStem HEALS and STIMULATES tissue and blood vessel growth, which has significant meaning the world of ED. Viagra and similar drugs work by increasing blood to the penis, and it works because just like a balloon you’re pumping it full of air. However, CaverStem essentially heals and repairs the damaged/blocked vessels by stimulating more to grow.
When introduced, Viagra and similar drugs were considered revolutionary in the world of ED. CaverStem, however, can one day be considered as a CURE.
This is why I consider this stock to be severely undervalued. If given the choice between a patch or a cure, which would you choose?
Also I know most of you have seen the procedure itself posted online. Bone marrow aspiration is a procedure that is commonly being done already for blood diseases, cancer, and other disorders. The only new thing that physicians need training for is how to operate the Magellan Cell Separator. Training shouldn’t be all that difficult.
I hope that this contributes something to your already established DD. Most of what I said could be taken from the articles posted on the official CaverStem website, but I wanted to simplify it because I know not a lot of people here work in the medical field.
I won’t be posting much here since between my rounds, patients, and other duties I only have free time to browse after my shift or during breaks. I will say, however, that I’m glad to be part of this ride with all the longs! Add me to the list of long holders: 300,000 strong. Not a lot compared to some of your millions, but it should be enough to help pay off part of my loan from medical school.
Ichim, T. E., Warbington, T., Cristea, O., Chin, J. L., & Patel, A. N. (2013). Intracavernous administration of bone marrow mononuclear cells: a new method of treating erectile dysfunction? Journal of Translational Medicine, 11, 139. http://doi.org/10.1186/1479-5876-11-139
Kasper, D. L., Fauci, A. S., Hauser, S. L., Longo, D. L. 1., Jameson, J. L., & Loscalzo, J. (2015). Harrison's principles of internal medicine (19th edition.). New York: McGraw Hill Education.
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