Replies to post #22734 on SiNtx Technologies Inc (SINT)

[boston745]

Plastic sucks dont get me wrong but based on studies ive found, its better than CoC. Si3N4 can reduce particlate loss and increase lifespan plus can help offset the plastic stimulated osteoclasts through inhibition and osteoblast stimulation.

[boston745]

59% of Zimmer's 2018 revenue was from Hip/Knee. Take that in for a second.

Can Zimmer afford to chance any other major ortho firm bringing Si3N4 hip/knee implant to market with what we currently know?

1. Si3N4 shows less wear against poly surfaces vs Biolox at 5mc.
2. Si3N4 theoretical wear rates appear to be less than CoCr at the taper junction ; biolox appears to show greater wear compared to CoCr at taper junction when paired with titanium stem.
3. Si3N4 wear particles can dissolve in bodily fluids, be excreted due to its solubility, and can aid the body in healing itself via Orthosilicic acid and ammonia which is used to feed cellular production.
4. Si3N4 removes oxygen from poly surfaces extending their potential life as oxygen is believed to degrade them thus potentially extending implant longevity.
5. Si3N4 coating over femoral stem can significantly reduce biological metal exposure plus potentially counteract osteoclasts that maybe stimulated by plastic particles reducing likelihood of loosening.
6. Si3N4 can resist bacterial infections and possibly eliminate any bacteria around implant site preventing potential implant failure.
7. Unlike DLC, TiN, etc.., Si3N4 has long term studies showing its in-vivo clinical biocompatiblity! 1 30 year study plus 10 years on the market exceeding 35,000 implants over that period.