1. Demonstrated P53 modulation in a preclinical settings. 2. Demonstrated improved results as a combo treatment in preclinical settings. 3. Proven safe at tested doses in a phase 1 clinical trial. 4. Showed p53 modulation in 2/2 patients in a phase 2 clinical trial. 5. Preclinical studies suggest bioavailability will be high enough to be effective when delivered orally.