I had seen the HSV research lately but had not necessarily made the connection with the Leaky BBB. Interesting thoughts on that. I have been doing some research on the Pdgf's for multiple sclerosis and bryostatin. There seems to be a connection. I'll try to make a post later that includes some links to that. Seems very promising at first glance
I think you'll find this one interesting, especially in the role that BBB leakage plays in MS. Also of note is the article is promoting BDNF as a biomarker for the disease as it ALWAYS declines with the onset of the disease and remains low. Of course we know of an effective way to increase BDNF lol. Cognitive decline occurs as MS progresses and low levels of BDNF are likely the cause. This research article is barely a year old too. Very exciting and confirmatory of our multi modal MOA. One day I truly believe we'll hear something from the company on MS and this board will have heard it first. JMHO as always
Been trying to look into this more ITT as I think the BBB hypothesis is rather new and a worthy thesis. Alkon even talked indirectly about the BBB issue in the late November interview discussing how TBI can play a role in Alzheiemer's and needs further study. Regardless this is one of the most recent articles on BBB studies. It specifically explains how "tight junction" proteins help to regulate a healthy BBB. These include claudin-5, occludin and ZO-1 which are important for the formation and maintenance of a functional BBB. It also explains what the BBB does "The BBB is a specialized regulator that separates the blood from the brain parenchyma. It effectively mediates the exchange of substances in the central nervous system, and its barrier structure restrains the influx of harmful substances and promotes essential nutrients to reach the brain." https://ac.els-cdn.com/S036192301830738X/1-s2.0-S036192301830738X-main.pdf?_tid=dd3df3fc-818b-400e-bd53-98bb5bcd94b6&acdnat=1548254793_2acac6eb5335c2c6c3e9e1bf073724b2
Now as for tight junction proteins claudin, occludin, and Z0-1, bryostatin, through the pkc process recruits these proteins to maintain the integrity of the BBB. This article was published a little over a year ago and shows how the BBB can be exposed to certain toxins and do damage by breaking down the PKC process and shutting down the recruitment of the helping proteins listed above. This example is to ethanol exposure. Even excessive drinking has been thought to contribute as mentioned in the article. https://www.spandidos-publications.com/10.3892/etm.2017.5180
"Brain microvascular endothelial cells (BMECs) are the primary component of the blood-brain barrier (BBB). Tight junction (TJ) proteins, including claudin, occludin and zonula occludens (ZO)-1, ZO-2 and ZO-3, maintain the structural integrity of BMECs. Ethanol activates the assembly and disassembly of TJs, which is a process that is regulated by protein kinase C (PKC). In addition, ethanol treatment leads to the loss of structural integrity, which damages the permeability of the BBB and subsequently affects central nervous system"
Now if one wonders if byostatin increases those tight junction proteins which protect the BBB integrity you can google "bryostatin" with "claudin", or "occludin" or "ZO-1". Here are just a couple links.
Still going to get around to the PDGF and Multiple sclerosis soon lol. I simply haven't found another drug or treatment that would be as stabilizing or repairing as bryostatin if indeed BBB damage plays any type of significant role here so wanted to put something together while I was thinking about it.
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