With stocks having issues like these noted below, it's really hard for retail investors to make a profit...
High, selling, general and administrative costs
High salaries and bonuses
Toxic debt
Stock dilution, reverse splits or warrants
Share structure, outstanding shares vs. authorized shares, vs. preferred shares
CEO's missing Q guidance's
CRL letters from the FDA
Outright rejection from the FDA
Lawsuits
Failed phase I, II or III trials
Negative publicity, even it's it fake news
Competition from other companies
OTC companies not being regulated
News 
Market Data 
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