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Sloan89RH

12/05/18 7:14 AM

#109837 RE: Play4keeps2 #109836

Thanks P4K2, but I think we'll hear a lot more about Theralink before we see much about OvaDx. Avant will focus their near term efforts on developing Theralink because of the greater potential it has for revenue and profit vis a vis OvaDx. OvaDx has further to go in the FDA approval pipeline. Importantly, Theralink has a much broader application than OvaDx and could revolutionize the way decisions are made to treat cancers. See below regarding Theralink:

Theralink® Tumor Biomarker Platform
The Theralink® assay technology uses reverse phase protein array (RPPA) technology to measure the quantity, activity, and downstream signaling pathway activation levels for receptors of FDA-approved and investigational drugs in order to determine whether or not a prescribed medication is likely to be effective in treating the cancer of a specific patient at that moment in time.

This highly sensitive analysis empowers physicians to make better treatment decisions by giving a greater degree of certainty as to whether a specific drug will work in treating a specific patient, as well as informing a physician whether a chemotherapy treatment is unlikely to be effective. This is also effective in patient selection in biopharmaceutical’s clinical trials. The information potentially allows the patient to forego the devastating side effects of cytotoxic treatments that are unlikely to deliver clinically meaningful benefits, while guiding physicians to prescribing treatments likely to yield maximum results.

Theralink® measures phosphorylated proteins in tumor tissue. Phosphorylated proteins represent active targets for drugs.