Replies to post #20940 on SiNtx Technologies Inc (SINT)

[boston745]

Clout and deep pockets is precisely what SiNTx needs.

Zimmer needs a new material something ive been saying for some time. Its needs something differentiating and thats not robotics. H1 if its Zimmers is but 1 product years away if they are doing a long-term study. However ZTA is not biologically compatible.

No one talks about Zimmers new board members and why Zimmer suddenly added 2 additional seats. Thats something usually done around mergers. I should also add that Zimmers supposed divestiture of its Dental unit seems more red herring than anything.

[boston745]

I think they are definitely paying attention considering the last Zimmer call seemed to include a direct rebuttal.

What are you referring to here?

[boston745]

Ive posted this before but ZTA CoC debris actually causes increased tissue inflammation compared to CoP & MoM. Would this not be an issue for H1?

Results
There was a significant increase in tissue fibrosis with implantation time for all implant types tested. Interestingly, the tissue fibrosis in ceramic-on-ceramic THAs was significantly increased compared with metal-on-metal and ceramic-on-polyethylene. Additionally, we found ceramic wear particles in the periprosthetic tissue of ceramic implants. Fibroblasts responded with expression of cytokines when cultured on alumina-toughened zirconia (ATZ) and zirconia-toughened alumina (ZTA) ceramic surfaces. This response was more pronounced on ATZ ceramics compared with ZTA ceramics. The same inflammatory response was observed with peripheral blood mononuclear cells (PBMCs) cultured on ZTA and ATZ.

Conclusion
Our findings therefore, corroborate the previous findings that ceramic-on-ceramic periprosthetic revision tissue is fibrous and offer an explanation for this observation. We detected a long-term inflammatory response of PBMCs and an inflammatory response of fibroblasts to ATZ and ZTA ceramic. These findings partially explain the fibrotic tissue change in periprosthetic tissue of ceramic-on-ceramic bearings.

https://online.boneandjoint.org.uk/doi/abs/10.1302/0301-620X.100B7.BJJ-2017-1590.R2?journalCode=bjj