Replies to post #20860 on SiNtx Technologies Inc (SINT)

[OhManIDied]

The released particles are essentially passivized by the body's immune system. This leads to other complications - inflammation and stress on the body.

CoCr and Ti are selected due to this not being as large of an issue but still more than ceramic.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793669/

Olmedo et al. (2003) [4] have observed that ionic release induced by corrosion could be responsible for peri-implantitis and treatment failure. Particles dissolved as a result of corrosion process are phagocytosized by macrophages (host response) and release mediators of inflammation in the form of cytokines (host defense), which inhibit the production of osteoblasts and promote osteolytic activity, leading to implant loosening. They found macrophages loaded with metal particles as indicators of the corrosion process in the soft peri-implant tissue of failed human dental implants.

The corrosion process may limit the metal’s resistance to fatigue, which may eventually cause the fracture of the implant. Guglielmotti and Cabrini (1997) [5] found metal particles included in the osseointegrated bone tissue of implants that failed due to metal fatigue, providing evidence of the corrosion of metallic structure.