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tika1

10/25/18 5:34 PM

#221626 RE: DewDiligence #221623

What is point to continuing testing if it failed at OS and PFS? Why are they wasting $$ which they don't have?

DewDiligence

03/07/19 5:22 PM

#223924 RE: DewDiligence #221623

SNDX -12%/AH on Entinostat failures in ovarian and TNBC:

https://www.prnewswire.com/news-releases/syndax-pharmaceuticals-reports-fourth-quarter-2018-financial-results-and-provides-clinical-and-business-update-300808834.html

The Phase 1b/2 ENCORE 603 trial, which evaluated entinostat in combination with avelumab in patients with heavily pretreated advanced epithelial ovarian cancer, and the Phase 1b/2 ENCORE 602 trial, which evaluated entinostat in combination with atezolizumab in patients with PD-1 naïve, previously treated TNBC, each failed to meet its respective primary endpoint of a statistically significant improvement in PFS.