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10/19/18 1:09 PM

#9989 RE: Staypositive1 #9988

I'd say that small research project w/ Sanofi

Is a lil more than small

Sanofi has a direct interest in gp41

Mymx will get some revs in time b/c they get a small piece in a license eventually for HIV w/ larger players than Catalent

& most likely across multiple diseases

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10/19/18 1:19 PM

#9990 RE: Staypositive1 #9988

transmembrane gp41 from clade B, and Gag/Pro from clade B and was used previously in the RV144 phase III clinical trial

https://jvi.asm.org/content/89/16/8525

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10/19/18 1:54 PM

#9992 RE: Staypositive1 #9988

Gilead's HIV Franchise Under Assault As It Stares Down Paradigm-Changing Drug

https://seekingalpha.com/article/4187810-gileads-hiv-franchise-assault-stares-paradigm-changing-drug

Other drug makers like GlaxoSmithKline (GSK), Johnson & Johnson (JNJ), Merck (MRK), and Bristol-Myers Squibb (BMY) round out the top 11 drugs for HIV and are looking for cracks in GILD’s HIV franchise to exploit. They are likely meeting with CYDY in anticipation of the approval, and if they get wind of a monotherapy filing, this could spark a fight for control of the next generation of HIV treatment.

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10/19/18 2:07 PM

#9993 RE: Staypositive1 #9988

T20 peptide (enfuvirtide) is the first U.S. FDA-approved HIV entry inhibitor; however, its clinical application is limited by the lack of oral availability

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775441/

Enfuvirtide binds to gp41 preventing the creation of an entry pore for the capsid of the virus, keeping it out of the cell

https://en.wikipedia.org/wiki/Enfuvirtide

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10/19/18 2:23 PM

#9994 RE: Staypositive1 #9988

Covalent stabilization of coiled coils of the HIV gp41 N region yields extremely potent and broad inhibitors of viral infection.

Rome, Italy. elisabetta.bianchi@merck.com

https://www.ncbi.nlm.nih.gov/pubmed/16129831

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10/19/18 7:28 PM

#10002 RE: Staypositive1 #9988