First of all, there are not many cases where you break the long term downtrend. Perhaps on any given day, only 1 out of 3000 stocks. You are going to watch all 3000 of them?
Two, you can't really say with certainty that resistance has been broken. And by the time you can, it may be too late. But you need to have a lot of trading experience to understand my point here.
Three, false breakouts are more rule than exception, these days. What this means is, you will buy at, say 0.38 but it drops to 0.34 the next day. You just got screwed by the hedgies. And then you panic, and sell.
Four, suppose you do get it right. You buy at 0.38. Now you have a problem at 0.44. Take profit or let it run? It does quite often fall back to 0.36 (which is now support) before moving higher again. After all, you don't know much about the company in the first place. So you will probably take profits too soon. Or not?