"Not totally meaningless- a small signal of efficacy legitimately led to P2b"
If this is the case then why do you constantly say it will fail. The longer it takes indicates failure.
Just the opposite. The longer the better in my estimation. If it was a failure then the data compilation would be stopped and no more money would be wasted.
So let this play out. All we are doing is guessing at this point. Not even an educated guess