Replies to post #26512 on Cytodyn Inc (CYDY)

[MJbiotech]

You can disagree all you want, the good thing about science is that it's true whether you believe it or not.

CYDY has added this statement to their recent press releases:

"PRO 140 does not have agonist activity toward CCR5 but does have antagonist activity to CCL5, which is a central mediator in inflammatory diseases."

As Misiu has pointed out, Pro140 is antagonistic for CCL5, which means it binds to CCR5 and does not allow CCL5 to bind. As CCL5 is a chemotactic cytokine that plays a role in T cell trafficking to inflammatory sites, Pro140 is affecting the normal function of CCR5. Again, there is not really any other way the drug can be effective in inflammatory diseases unless this was the case.