Replies to post #26491 on Cytodyn Inc (CYDY)

[misiu143]

IMO this is different , no immune problems in this patients but CCR5 is blocked ,

I believe that those patients might develop more severe form of West Nile Virus , according to all article I could find ,

But all of this is new to me too , so this is just from my reading and my understanding ..

Nt2 , please , what is your opinion here .
Thank you .

[EponymousKook]

That’s what I was thinking. This could be another factor in our favour.

[misiu143]

I just send an email to Dr Pestell with this question. I send to ProstoGene email address.
When/if I will receive his answer I will post it here ..

[MJbiotech]

If Pro140 just blocked HIV entry and "allowed the receptor to function as it should otherwise" then Pro140 would NOT be effective in GvHD, Cancer, and any other immunological application that's been suggested in the past.

Pro140 certainly alters ability of chemokines to bind to CCR5 - it would have to for Pro140 to work in GvHD. Same holds true in Pestell's cancer models. Does this result in an overall negative effects to the immune system? It doesn't appear so. There is some literature to suggest that CCR5 is more of a problem causing receptor, and that its not necessary for basic immune system function.