Replies to post #235345 on Innovation Pharmaceuticals Inc (IPIX)

[bradfordbros]

Total rubbish, in fact it's an incentive to bps out there to look at b.

[Empiricst1]

Not necessarily, there is a good chance that Brilacidin will address MDR bacterial strains. Wide open area, need lots of new anti-biotics. The world population is getting bigger, climate change and political unrest means more migrations, etc. The market is untapped.

[PlentyParanoid]

Well, I don't know about that. From the FDA label for plazomicin:

WARNING: NEPHROTOXICITY, OTOTOXICITY,
NEUROMUSCULAR BLOCKADE and FETAL HARM
See full prescribing information for complete boxed warning.
1. Nephrotoxicity has been reported with ZEMDRI. The risk
of nephrotoxicity is greater in patients with impaired renal
function, the elderly, and in those receiving concomitant
nephrotoxic medications. (5.1)
2. Ototoxicity, manifested as hearing loss, tinnitus, and/or
vertigo, has been reported with ZEMDRI. Symptoms of
aminoglycoside associated ototoxicity may be irreversible
and may not become evident until after completion of
therapy. (5.2)
3. Aminoglycosides have been associated with neuromuscular
blockade. During therapy with ZEMDRI, monitor for
adverse reactions associated with neuromuscular blockade
particularly in high-risk patients. (5.3)
4. Aminoglycosides, including ZEMDRI can cause fetal harm
when administered to a pregnant woman. (5.6, 8.1)

If my memory is not failing me it's the elderly and pregnant women who tend to get urinary tract infections- and, in my storied past, me due to a mistake of cooling my bare bottom plus 'culottes' on a cold granite bench after a visit to really hot sauna (further details not forthcoming!)