"As such we anticipate revenue from services during the three months ended to March 31, 2018 to be in the range of $195 million to $215 million, which include the impact of volume fluctuations, the impact of PAMA and other reimbursement challenges we faced during 2017 as well as the accounting changes I previously mentioned.
Moving to RAYALDEE, we anticipate first quarter revenues will be between $3.5 million and $5 million, which reflect a range of estimates to our gross to net calculations as well as our expectations for volume trends. In addition, we expect the first quarter operating expenses for our investments in R&D as well as the RAYALDEE commercial team to be approximately $35 million and $8 million respectively."