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jq1234

04/18/18 10:58 PM

#218591 RE: JohnWayne #218590

Ok, I see you were talking about OS co-primary endpoint. The reason BMY selected that is most likely to preserve CheckMate-227 Part 1a trial (Nivolumab + ipilimumab vs Nivolumab vs chemo in PD-L1+) completely. In case PFS co-primary in TMB fails or regulators consider it post hoc, they at least have something to fall on based entirely on prespecificed portion of trial.