IMO, everyone invested now has taken the "ahead of the pack" approach. Meaning, it doesn't matter what percentage of market share IME could potentially capture. The goal is a spike on price due to a buyout offer and/or positive results of clinical trials. I for one will not be holding shares into oblivion. A Billion Dollar valuation would be the maximum threshold. IMO, it's a market valuation that's easily attainable and peanuts for a Big Pharma buyout deal.