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PlentyParanoid

03/28/18 9:58 AM

#222619 RE: MinnieM #222492

Thanks for the links Karin. I read the first one yesterday - heavy. It probably will sink in with few more reads. Coincidentally, I was being angry with myself over placebo response when I noticed your message. There has been a little fact hiding in front of my nose for a long, long time:

I don't know how much weight one should put on these observation:

1 Placebo response PASI 100 and PGA 0 are historically very low, from 0 to 1 %.
2. Prurisol PGA 0 was for 200 mg ITT: 3/28 or 10.7 % and PGA=3: 2/18 or 11.1 %.
3. Prurisol PGA 0 percentages are in the range of Otezla PASI 90 percentages, which indicates that they are roughly at least twice that of Otezla PGA 0 response- nobody has bothered to report PGA 0 or PASI 100 for Otezla, as far as I know.