Replies to post #220605 on Innovation Pharmaceuticals Inc (IPIX)

[pix]

If prolonged linear or non linear dose response, we should see better efficacy.

If already plateaued, not.

This is what the trial is to determine...

Tc

[To infinity and beyond!]

how does any company find the right dose for any drug? does it make even the slightest sense that more is always better? That more prurisol always means a better response? That is not how science works, as I am sure you know. More of any drug may cause more harm than good- finding the balance is the essence of medicinal chemistry

[frrol]

Your response "Higher dose, easier trial" is not coherent.

I see some folks have responded already, and I know you didn't rule out at least a plateau. That's not exactly what I am referring to. The 200mg dosage may not only have been the plateau, but luck may have it that our trial arm may also have been on the high end of effect. Always, always keep in mind that there is volatility in trial results. So >200mg doses have a chance of resulting in slightly "lower" efficacy even if 200mg (and higher) is the plateau. This is statistically speaking. It should be noted that the opposite is possible too: the higher doses could result in slightly "higher" effect even if 200mg (and higher) was the plateau.

If you still don't understand: think about what happened to efficacy results in our B-OM trial, comparing interim results to final. Did B as a drug somehow get 'less effective' later in the trial? Of course not. I give this as a great example of results volatility. Combine that with the chance of dosage plateau, and you can understand how your assertion was false.

But what is valid is stating that if 200mg is not the plateau for P, it is likely we will see as good or better results at the higher doses. That is not as satisfying a statement, but it is an accurate one.