MYOK ...Nowlurking ...Paradigm -HF was an Outcome trial .. Entresto is a combination drug ( Sacubitril / Valsartan ). I do not know the history of Sacubitril but Valsartan was approved in 2002 .
The MYOK trial you referred to is designed with FDA input and accepted by them . There will be a long term safety follow up for this trial . Its not an Outcome trial .
I intend to stay long into the March 10th ACC data presentation . Kiwi