Replies to post #284765 on Elite Pharmaceuticals Inc (ELTP)

[Investintin]

Pro-drugs are cute but not abuse deterrent

Hahaha wow!!

Prodrugs may be inherently abuse-deterrent because they are inactive or significantly less active until conversion to the active drug. This requirement for conversion in the GI tract can modify the pharmacokinetic profile and eliminate or reduce the euphoria when abusers change the route of administration

https://www.ncbi.nlm.nih.gov/pubmed/26615852

Prodrugs are biologically inactive substances that are metabolized inside the body to their active form. Development of a prodrug that lacks opioid activity until it has been metabolized in the
gastrointestinal (GI) tract may be an attractive option to prevent
IV or intranasal routes of abuse.

http://abusedeterrent.org/Resources/Docs/AD-Coalition-Pain-Medicine-News-April-2015.pdf

Kempharm's studies show that there is a decrease in plasma concentration when *EIGHT* (8!!!) tablets are taken. In other words, not much help

I thought preventing dead by lowering the concentration in plasma was good... I guess I was wrong ;)

Don't believe anything you hear until the data is available to prove it.

COMPLETELY AGREE! lets start with those made up pathways to dollarland and 'imminent' approvals ;)